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The F Gene of Rodent Brain-Adapted Mumps Virus Is a Major Determinant of Neurovirulence

3 May 2007

Abstract excerpt

Prior to the introduction of live-attenuated vaccines, mumps virus (MuV) was the leading cause of virus-induced meningitis. Although vaccination has been effective at controlling the disease, the use of insufficiently attenuated strains has been associated with high rates of aseptic meningitis in vaccinees. The molecular basis of MuV attenuation is poorly understood, and no reliable molecular markers of virulence...

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PMID: 17475640
DOI: 10.1128/jvi.00266-07

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Source receipt: pubmed, retrieved 7 Sept 2026.

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