Article
Chloroquine-resistant Plasmodium falciparum infections among UK travellers returning with malaria after chloroquine prophylaxis.
The Journal of antimicrobial chemotherapy - 1 Jun 2007
Sutherland Colin J, Haustein Thomas, Gadalla Nahla, Armstrong Margaret, Doherty Justin F, Chiodini Peter L
Abstract excerpt
OBJECTIVES: We sought to identify chloroquine-resistant Plasmodium falciparum parasites among 66 travellers who presented in the UK with malaria. METHODS: A multiplex real-time PCR assay was devised to identify wild-type and two distinct chloroquine-resistance-associated alleles of the pfcrt gene. RESULTS: Those with documented use of chloroquine/proguanil prophylaxis were more likely to carry parasites with...
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