Article
Inhibitors of bacterial virulence identified in a surrogate host model.
Cellular microbiology - 1 May 2007
Benghezal Mohammed, Adam Eric, Lucas Aurore, Burn Christine, Orchard Michael G, Deuschel Christine, Valentino Emilio, Braillard Stéphanie, Paccaud Jean-Pierre, Cosson Pierre
Abstract excerpt
Antibiotic resistance continues to reduce the number of available antibiotics, increasing the need for novel antibacterial drugs. Since the seminal work of Sir Alexander Fleming, antibiotic identification has been based exclusively on the inhibition of bacterial growth in vitro. Recently, inhibitors of bacterial virulence which interfere with bacterial pathogenesis mechanisms have been proposed as an alternative...
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