Article
Estimating cancer risk in HNPCC by the GRL method.
European journal of human genetics : EJHG - 1 Aug 2007
Alarcon Flora, Lasset Christine, Carayol Jérôme, Bonadona Valérie, Perdry Hervé, Desseigne Françoise, Wang Qing, Bonaïti-Pellié Catherine
Abstract excerpt
Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant syndrome caused by germline mutations of the mismatch repair (MMR) genes. Only a few studies have taken into account the selection of families tested for these mutations in estimating colorectal cancer (CRC) risk in carriers. They found much lower estimates of CRC risks than previous ones, but these estimates lacked precision despite the...
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