Article
Associations between the PTPN22 1858C->T polymorphism and radiographic joint destruction in patients with rheumatoid arthritis: results from a 10-year longitudinal study.
Annals of the rheumatic diseases - 1 Dec 2007
Lie Benedicte A, Viken Marte K, Odegård Sigrid, van der Heijde Désirée, Landewé Robert, Uhlig Till, Kvien Tore K
Abstract excerpt
OBJECTIVE: To investigate whether the PTPN22 1858T risk variant is associated with the rate of radiographic progression in rheumatoid arthritis (RA). METHODS: A longitudinally followed cohort of 238 Norwegian patients with RA (the EURIDISS cohort) was genotyped for the PTPN22 1858C-->T polymorphism. Radiographic damage was assessed by hand radiographs at baseline and after 1, 2, 5 and 10 years, and the...
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