Article
The pathogenesis of osteonecrosis.
Instructional course lectures - 1 Jan 2007
Jones Lynne C, Hungerford David S
Abstract excerpt
Although numerous studies concerning the pathogenesis of osteonecrosis have been published, the pathophysiologic mechanisms that may be involved continue to be debated. In the early 1980s, the concept of accumulative cell stress was advanced, which is a theory that proposes that bone cells are exposed to multiple insults or stresses, the effects of which accumulate to the point that the cells cannot sustain...
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