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Article

CD4 +CD25 + regulatory T cells decreased the antitumor activity of cytokine-induced killer (CIK) cells of lung cancer patients.

Journal of clinical immunology - 1 May 2007

Li Hui, Yu Jin-Pu, Cao Shui, Wei Feng, Zhang Peng, An Xiu-Mei, Huang Zong-Tang, Ren Xiu-Bao

Abstract excerpt

: CD(4) (+)CD(25) (+) regulatory T cells (Tregs) have been shown to inhibit cytotoxic lymphocytes-mediated immune responses. Cytokine-induced killer (CIK) cells exert high impact on adoptive immunotherapeutic approaches. Therefore, the purpose of this report was to determine the effect of Tregs on CIK cell growth and CIK-induced cytotoxicity for inhibition of tumor growth in vivo as well as in vitro. After...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17468835
DOI: 10.1007/s10875-007-9076-0

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