Article
Gemcitabine treatment enhanced the anti-tumor effect of cytokine induced killer cells by depletion of CD4+CD25bri regulatory T cells.
Immunology letters - 1 Jan 2017
Zhao Peng, Zhu Danni, Zhang Zhen, Han Bin, Gao Daiqing, Wei Xiaofang, Xie Xihe, Li Changyou, Sun Weihong, Wang Qingqing, Guo Qingming
Abstract excerpt
Cytokine induced killer (CIK) cells have a powerful tumor cells killing activity both in vitro and in vivo and transfusion of these cells have become an adjuvant treatment for tumors. CIK cells are induced and amplified from peripheral blood mononuclear cells (PBMCs) with multiple cytokines. As CD4+CD25bri regulatory T cells can be also induced by high dose of interleukin 2 (IL-2) which is used for CIK cells...
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