Article
Failure to confirm association between PDCD1 polymorphisms and rheumatoid arthritis in a Japanese population.
Journal of human genetics - 1 Jan 2007
Iwamoto Takuji, Ikari Katsunori, Inoue Eisuke, Toyama Yoshiaki, Hara Masako, Yamanaka Hisashi, Tomatsu Taisuke, Momohara Shigeki, Kamatani Naoyuki
Abstract excerpt
Programmed cell death 1 (PDCD1) is a necessary negative regulator to maintain peripheral tolerance and is a key molecule in the development of autoimmune diseases. Although PDCD1 gene polymorphisms and haplotypes were reported to be associated with rheumatoid arthritis (RA), replication studies later on showed conflicting results. Here, we analyzed the association of PDCD1 with RA using a large series of Japanese...
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