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Article

Dietary flavonoids induce MLL translocations in primary human CD34+ cells

29 Apr 2007

Abstract excerpt

Genetic abnormalities leading to infant leukemias already occur during fetal development and often involve rearrangements of the mixed-lineage leukemia (MLL) gene. These rearrangements resemble the aberrations observed in therapy-related leukemias following treatment with topoisomerase II (topoII)-inhibiting agents such as etoposide. Since flavonoids are potent topoII inhibitors, we examined the role of three...

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PMID: 17468513
DOI: 10.1093/carcin/bgm102

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