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Article

Etoposide induces MLL rearrangements and other chromosomal abnormalities in human embryonic stem cells

8 Jul 2009

Abstract excerpt

MLL rearrangements are hallmark genetic abnormalities in infant leukemia known to arise in utero. They can be induced during human prenatal development upon exposure to etoposide. We also hypothesize that chronic exposure to etoposide might render cells more susceptible to other genomic insults. Here, for the first time, human embryonic stem cells (hESCs) were used as a model to test the effects of etoposide on...

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PMID: 19587093
DOI: 10.1093/carcin/bgp169

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