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Article

Prenatal exposure to flavonoids: implication for cancer risk.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Mar 2011

Vanhees Kimberly, de Bock Laura, Godschalk Roger W L, van Schooten Frederik J, van Waalwijk van Doorn-Khosrovani Sahar Barjesteh

Abstract excerpt

Flavonoids are potent antioxidants, freely available as high-dose dietary supplements. However, they can induce DNA double-strand breaks (DSB) and rearrangements in the mixed-lineage leukemia (MLL) gene, which are frequently observed in childhood leukemia. We hypothesize that a deficient DSB repair, as a result of an Atm mutation, may reinforce the clastogenic effect of dietary flavonoids and increase the...

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Identifiers

PMID: 21177254
DOI: 10.1093/toxsci/kfq388

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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