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Article

Development of Pyrosequencing Method for Detection of UGT1A1 Polymorphisms in Thai Colorectal Cancers.

Journal of clinical laboratory analysis - 1 Jan 2016

Sukasem Chonlaphat, Atasilp Chalirmporn, Chansriwong Pichai, Chamnanphon Montri, Puangpetch Apichaya, Sirachainan Ekapob

Abstract excerpt

BACKGROUND: UGT1A1 is a polymorphic enzyme that has been associated with irinotecan drug metabolisms. We developed a pyrosequencing method to detect allele frequency and genotype of UGT1A1 polymorphisms (UGT1A1*28 and UGT1A1*6) in Thai colorectal cancer patients. METHOD: A pyrosequencing method was designed to determine UGT1A1 genetic polymorphisms including UGT1A1*28 (A[TA]7TAA) and UGT1A1*6 (211G>A) in 91 Thai...

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Identifiers

PMID: 25545261
DOI: 10.1002/jcla.21820
PMCID: PMC6807135

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