Article
Genetic association between Notch4 polymorphisms and Alzheimer's disease in the Japanese population.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Apr 2007
Shibata Nobuto, Ohnuma Tohru, Higashi Shinji, Higashi Maiko, Usui Chie, Ohkubo Taku, Watanabe Tomoko, Kawashima Ritsuko, Kitajima Akiyoshi, Ueki Akira, Nagao Masatsugu, Arai Heii
Abstract excerpt
It is shown that Notch 4 plays important roles in the pathogenesis of Alzheimer's disease (AD). To investigate whether three single nucleotide polymorphisms (SNPs) of the Notch4 gene are associated with AD, the three SNPs were genotyped by a polymerase chain reaction-restriction fragment length polymorphism method for 243 AD patients and 130 age-matched controls. We also confirmed the linkage disequilibrium among...
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