Article
Modifications of arterial phenotype in response to amine oxidase inhibition by semicarbazide.
Hypertension (Dallas, Tex. : 1979) - 1 Jul 2007
Mercier Nathalie, El Hadri Khadija, Osborne-Pellegrin Mary, Nehme Johnny, Perret Claudine, Labat Carlos, Regnault Veronique, Lamazière Jean-Marie Daniel, Challande Pascal, Lacolley Patrick, Fève Bruno
Abstract excerpt
Semicarbazide-sensitive amine oxidase (SSAO)-deficient mice present no alteration in elastin cross-linking processes and carotid mechanical properties. In contrast, previous studies have shown that SSAO inhibitors induced marked anomalies in arterial structure and function. The aim of the present study was to examine the effect of semicarbazide (SCZ), an efficient SSAO inhibitor, on the arterial phenotype of the...
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