Article
High-affinity interaction between HIV-1 Vpr and specific sequences that span the C/EBP and adjacent NF-kappaB sites within the HIV-1 LTR correlate with HIV-1-associated dementia.
DNA and cell biology - 1 Apr 2004
Burdo Tricia H, Nonnemacher Michael, Irish Bryan P, Choi Catherine H, Krebs Fred C, Gartner Suzanne, Wigdahl Brian
Abstract excerpt
Numerous host and viral factors likely participate in the onset and progression of HIV-1-associated dementia (HIVD). Previous studies have suggested that viral gene expression in resident central nervous system (CNS) cells of monocyte/macrophage lineage play a central role in the production of neurotoxic viral proteins and infectious virus, deregulation of cellular gene expression, and/or dysfunction of glial and...
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