Article
Clinical and neuropathological features of the arctic APP gene mutation causing early-onset Alzheimer disease.
Archives of neurology - 1 Apr 2008
Basun Hans, Bogdanovic Nenad, Ingelsson Martin, Almkvist Ove, Näslund Jan, Axelman Karin, Bird Thomas D, Nochlin David, Schellenberg Gerard D, Wahlund Lars-Olof, Lannfelt Lars
Abstract excerpt
BACKGROUND: A majority of mutations within the beta-amyloid region of the amyloid precursor protein (APP) gene cause inherited forms of intracerebral hemorrhage. Most of these mutations may also cause cognitive impairment, but the Arctic APP mutation is the only known intra-beta-amyloid mutation to date causing the more typical clinical picture of Alzheimer disease. OBJECTIVE: To describe features of 1 Swedish...
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