Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sp1 and Sp3 regulate glucokinase gene transcription in the liver of gilthead sea bream (Sparus aurata).

Journal of molecular endocrinology - 1 Apr 2007

Egea M, Metón I, Baanante I V

Abstract excerpt

To better understand the transcriptional machinery that governs glucokinase (GCK) expression, we have cloned and characterized the proximal promoter region of GCK from gilthead sea bream (Sparus aurata). The 5'-flanking region of GCK was isolated by chromosome walking. SMART RACE-PCR allowed us to locate the transcription start site 98 bp (bp) upstream from the translational start. Transfection analysis in HepG2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5' Flanking Region
Share to Cell Line, Tumor
Share to Cloning, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glucokinase

Share to Protein Kinases

Share to Sp3 Transcription Factor

Share to Transcription Initiation Site

Source

Identifiers

PMID: 17446237
DOI: 10.1677/jme.1.02176

Genes

GCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sp1 and Sp3 regulate glucokinase gene transcription in the liver of gilthead sea bream (Sparus aurata).PMID 17446237Read ↗

Identification of a novel beta-cell glucokinase (GCK) promoter mutation (-71G>C) that modulates GCK gene expression through loss of allele-specific Sp1 binding causing mild fasting hyperglycemia in humans.Semantic proximity Read ↗

Gene expression of the human glucagon-like peptide-1 receptor is regulated by Sp1 and Sp3.Semantic proximity Read ↗

Sp/Krüppel-like transcription factors are essential for the expression of mitochondrial glycerol phosphate dehydrogenase promoter B.Semantic proximity Read ↗

Genomic structure and sequence of the gilthead seabream (Sparus aurata) growth hormone-encoding gene: identification of minisatellite polymorphism in intron I.Semantic proximity Read ↗

Regulation of the human Na+-glucose cotransporter gene,SGLT1, by HNF-1 and Sp1Semantic proximity Read ↗

O-Linked N-acetylglucosaminylation of Sp1 interferes with Sp1 activation of glycolytic genes.Semantic proximity Read ↗

Functional analyses of natural variation in Sp1 binding sites of a TATA-less promoter.Semantic proximity Read ↗

Characterization of the 5' flanking region of the growth hormone gene of the marine teleost, gilthead sea bream Sparus aurata: analysis of a polymorphic microsatellite in the proximal promoterSemantic proximity Read ↗

Functional characterization of the proximal promoter of the murine pyruvate carboxylase gene in hepatocytes: role of multiple gc boxes.Semantic proximity Read ↗

Role of upstream stimulatory factor 2 in glutamate dehydrogenase gene transcription.Semantic proximity Read ↗

Transactivation of cytosolic alanine aminotransferase gene promoter by p300 and c-Myb.Semantic proximity Read ↗

Involvement of nuclear transcription factor Sp1 in regulating glucose transporter-1 gene expression during rat trophoblast differentiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.