Article
Sequencing-based typing identifies novel alleles due to single nucleotide polymorphisms in 'conserved' regions.
Tissue antigens - 1 Apr 2007
Smith L K, Sayer D C, Whidborne R S, Christiansen F T
Abstract excerpt
The Royal Perth Hospital laboratory has been using sequencing-based typing for all HLA loci since 2002. In the period to October 2005, approximately 12,000 HLA A and HLA B, 5000 HLA C and DQB1, and 17,000 DRB1 requests have been processed. Twenty nine novel alleles have been identified in that time. These comprise 10 HLA-A (including one null allele), five HLA-B, six HLA-C, six DRB1 (including a null allele), and...
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