Sequencing-based typing identifies novel alleles due to single nucleotide polymorphisms in 'conserved' regions.

doi:10.1111/j.1399-0039.2006.760_2.x

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Article

Sequencing-based typing identifies novel alleles due to single nucleotide polymorphisms in 'conserved' regions.

Tissue antigens - 1 Apr 2007

Smith L K, Sayer D C, Whidborne R S, Christiansen F T

Abstract excerpt

The Royal Perth Hospital laboratory has been using sequencing-based typing for all HLA loci since 2002. In the period to October 2005, approximately 12,000 HLA A and HLA B, 5000 HLA C and DQB1, and 17,000 DRB1 requests have been processed. Twenty nine novel alleles have been identified in that ti...

Topics

Alleles
Conserved Sequence
HLA Antigens
Haplotypes
Humans
Molecular Sequence Data
Polymorphism, Single Nucleotide
Sequence Analysis, DNA

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