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Article

Theoretical prediction of the p53 gene mutagenic mechanism induced by trans-4-hydroxy-2-nonenal.

The journal of physical chemistry. B - 17 May 2007

Xing Dianxiang, Sun Lixiang, Cukier Robert I, Bu Yuxiang

Abstract excerpt

The reaction mechanism of guanine with trans-4-hydroxyl-2-nonenal (4-HNE) and the mutagenic mechanism induced by adducts have been theoretically predicted at a molecular level from the energy point of view. 4-HNE directly reacts with guanine via three steps, yielding eventually four main diastere...

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PMID: 17439265
DOI: 10.1021/jp0673922

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17439265-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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