Risk of human T-lymphotropic virus type I-associated diseases in Jamaica with common HLA types.

doi:10.1002/ijc.22767

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Article

Risk of human T-lymphotropic virus type I-associated diseases in Jamaica with common HLA types.

International journal of cancer - 1 Sept 2007

Goedert James J, Li Hong-Chuan, Gao Xiao-Jiang, Chatterjee Nilanjan, Sonoda Shunro, Biggar Robert J, Cranston Beverley, Kim Norma, Carrington Mary, Morgan Owen, Hanchard Barrie, Hisada Michie

Abstract excerpt

Human T-lymphotropic virus-I (HTLV-I) causes adult T-cell leukemia/lymphoma (ATL) and HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP). We postulated a higher disease risk for people with common human leukocyte antigen (HLA) types, due to a narrower immune response against viral or neoplastic antigens, compared to people with uncommon types. HLA class-I (A,B) and class-II (DRB1, DQB1) allele and...

Topics

Alleles
HLA Antigens
HTLV-I Infections
Humans
Jamaica
Prevalence
Risk Factors

Source

Open in PubMed

Identifiers

PMID: 17437273
DOI: 10.1002/ijc.22767

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