Article
Identification of a unique specificity determinant of the colicin E3 immunity protein.
Gene - 30 Oct 1991
Masaki H, Akutsu A, Uozumi T, Ohta T
Abstract excerpt
Plasmid immunity to a nuclease-type colicin is defined by the specific binding of an immunity (or inhibitor) protein, Imm, to the C-terminal nuclease domain, T2A, of the colicin molecule. Whereas most regions of colicin operons exhibit extensive sequence identity, the small plasmid region encoding T2A and Imm is exceptionally varied. Since immunity is essential for the survival of the potentially lethal colicin...
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