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Article

Investigation of the specificity of the interaction between colicin E9 and its immunity protein by site-directed mutagenesis.

Molecular microbiology - 1 Nov 1991

Curtis M D, James R

Abstract excerpt

Comparison of the amino acid sequences of the C-terminal domain of three DNAase type E colicins has identified six candidate specificity determinants for the interaction of these E colicins with their homologous immunity proteins. We have changed these candidate specificity determinants of colicin E9, using site-directed mutagenesis, to the corresponding amino-acids of colicin E8. A 'mutant' colicin E9, in which...

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Identifiers

PMID: 1779762
DOI: 10.1111/j.1365-2958.1991.tb01981.x

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Related research

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Investigation of the specificity of the interaction between colicin E9 and its immunity protein by site-directed mutagenesis.PMID 1779762Read ↗

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Molecular basis of inhibition of the ribonuclease activity in colicin E5 by its cognate immunity protein.Semantic proximity Read ↗

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Characterisation of the ColE8 plasmid, a new member of the group E colicin plasmids.Semantic proximity Read ↗

Following evolutionary paths to protein-protein interactions with high affinity and selectivity.Semantic proximity Read ↗

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Intramembrane helix-helix interactions as the basis of inhibition of the colicin E1 ion channel by its immunity protein.Semantic proximity Read ↗

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Immunity protein release from a cell-bound nuclease colicin complex requires global conformational rearrangement.Semantic proximity Read ↗

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