Article
Fenofibrate effect on triglyceride and postprandial response of apolipoprotein A5 variants: the GOLDN study.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2007
Lai Chao-Qiang, Arnett Donna K, Corella Dolores, Straka Robert J, Tsai Michael Y, Peacock James M, Adiconis Xian, Parnell Laurence D, Hixson James E, Province Michael A, Ordovas Jose M
Abstract excerpt
OBJECTIVE: Apolipoprotein A5 (APOA5) is a key determinant of plasma triglyceride (TG) concentrations. Genetic variation at the APOA5 locus could be responsible for some of the observed differences in response to fenofibrate therapy. METHODS AND RESULTS: We examined the association between tag SNPs (-1131T>C and 56C>G) at APOA5 and TG and HDL-C response to fenofibrate and a postprandial lipid challenge in 791 men...
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