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CYP2D6 genotype in relation to perphenazine concentration and pituitary pharmacodynamic tissue sensitivity in Asians: CYP2D6-serotonin-dopamine crosstalk revisited.

Pharmacogenetics and genomics - 1 May 2007

Ozdemir Vural, Bertilsson Leif, Miura Jun, Carpenter Erin, Reist Christopher, Harper Patricia, Widén Jolanta, Svensson Jan-Olof, Albers Lawrence J, Kennedy James L, Endrenyi Laszlo, Kalow Werner

Abstract excerpt

OBJECTIVES: Hyperprolactinemia is a common side effect of first-generation antipsychotics mediated by antagonism of dopaminergic neurotransmission in the pituitary. Most first-generation antipsychotics are metabolized by CYP2D6 in the liver. Further, CYP2D6 is expressed in the human brain as a 5-methoxyindolethylamine O-demethylase potentially contributing to regeneration of serotonin from 5-methoxytryptamine. As...

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PMID: 17429316
DOI: 10.1097/FPC.0b013e32801a3c10

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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