Article
Targeting the Akt/mTOR pathway in Brca1-deficient cancers.
Oncogene - 26 May 2011
Xiang T, Jia Y, Sherris D, Li S, Wang H, Lu D, Yang Q
Abstract excerpt
The breast cancer susceptibility gene 1 (Brca1) has a key role in both hereditary and sporadic mammary tumorigenesis. However, the reasons why Brca1-deficiency leads to the development of cancer are not clearly understood. Activation of Akt kinase is one of the most common molecular alterations associated with human malignancy. Increased Akt kinase activity has been reported in most breast cancers. We previously...
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