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Article

Epi-allelic Erk1 and Erk2 knockdown series for quantitative analysis of T cell Erk regulation and IL-2 production.

Molecular immunology - 1 May 2007

Wille Lucia, Kemp Melissa L, Sandy Peter, Lewis Christina L, Lauffenburger Douglas A

Abstract excerpt

Erk activation is often used as a downstream pathway indicator of TCR signaling, generally in terms of both Erk1 and Erk2 isoforms measured together. In order to investigate potential distinctions between Erk1 and Erk2 regulation and effects downstream of TCR ligation, we generated a series of stable and independent Erk1 and Erk2 shRNA knockdown lines in the 1B6 T cell hybridoma. We observed no compensatory...

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Identifiers

PMID: 17418417
DOI: 10.1016/j.molimm.2007.02.008
PMCID: PMC2692299

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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