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Article

Novel APC mutations in Czech and Slovak FAP families: clinical and genetic aspects.

BMC medical genetics - 5 Apr 2007

Stekrova Jitka, Sulova Martina, Kebrdlova Vera, Zidkova Katerina, Kotlas Jaroslav, Ilencikova Denisa, Vesela Kamila, Kohoutova Milada

Abstract excerpt

BACKGROUND: Germline mutations in the adenomatous polyposis gene (APC) result in familial adenomatous polyposis (FAP). FAP is an autosomal dominantly inherited disorder predisposing to colorectal cancer. Typical FAP is characterized by hundreds to thousands of colorectal adenomatous polyps and by several extracolonic manifestations. An attenuated form of polyposis (AFAP) is characterized by less than 100 adenomas...

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Source

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Identifiers

PMID: 17411426
DOI: 10.1186/1471-2350-8-16
PMCID: PMC1853078

Genes

FAP
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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