Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Over-expression of parathyroid hormone Type 1 receptor confers an aggressive phenotype in osteosarcoma.

International journal of cancer - 1 Sept 2007

Yang Rui, Hoang Bang H, Kubo Tadahiko, Kawano Hirotaka, Chou Alexander, Sowers Rebecca, Huvos Andrew G, Meyers Paul A, Healey John H, Gorlick Richard

Abstract excerpt

Osteosarcoma is the most common primary bone malignancy in children and is associated with rapid bone growth. Parathyroid hormone-related peptide (PTHrP) signaling via parathyroid hormone Type 1 receptor (PTHR1) is important for skeletal development and is involved in bone metastases in other tumors. The aim of this study was to investigate the status of PTHrP/PTHR1 and its possible role in osteosarcoma. In a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Proliferation
Share to DNA, Complementary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Metastasis

Share to Osteoclasts

Share to Osteosarcoma

Share to Receptor, Parathyroid Hormone, Type 1

Share to RNA Interference

Share to Transforming Growth Factor beta1

Source

Identifiers

PMID: 17410535
DOI: 10.1002/ijc.22749

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Over-expression of parathyroid hormone Type 1 receptor confers an aggressive phenotype in osteosarcoma.PMID 17410535Read ↗

SERPINH1 enhances the malignancy of osteosarcoma via PI3K-Akt signaling pathwaySemantic proximity Read ↗

IR/IGF1R signaling as potential target for treatment of high-grade osteosarcomaSemantic proximity Read ↗

Wnt/β‐Catenin Signaling Activates Expression of the Bone‐Related Transcription Factor RUNX2 in Select Human Osteosarcoma Cell TypesSemantic proximity Read ↗

Activated parathyroid hormone/parathyroid hormone-related protein receptor in osteoblastic cells differentially affects cortical and trabecular bone.Semantic proximity Read ↗

A mutant PTH/PTHrP type I receptor in enchondromatosis.Semantic proximity Read ↗

Seven BMPs and all their receptors are simultaneously expressed in osteosarcoma cellsSemantic proximity Read ↗

The expression of P-glycoprotein is causally related to a less aggressive phenotype in human osteosarcoma cells.Semantic proximity Read ↗

Hypoxia induces PTHrP gene transcription in human cancer cells through the HIF-2αSemantic proximity Read ↗

BMP-2 inhibits the tumorigenicity of cancer stem cells in human osteosarcoma OS99-1 cell lineSemantic proximity Read ↗

Human osteosarcoma cells express functional receptor activator of nuclear factor‐kappa BSemantic proximity Read ↗

Conditionally immortalized murine osteoblasts lacking the type 1 PTH/PTHrP receptor.Semantic proximity Read ↗

Disruption of β-catenin binding to parathyroid hormone (PTH) receptor inhibits PTH-stimulated ERK1/2 activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.