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Article

Dual role of inactivating Lef1 mutations in epidermis: tumor promotion and specification of tumor type.

Cancer research - 1 Apr 2007

Niemann Catherin, Owens David M, Schettina Peter, Watt Fiona M

Abstract excerpt

The NH(2) terminus of LEF1 is frequently mutated in human sebaceous tumors. To investigate how this contributes to cancer, we did two-stage chemical carcinogenesis on K14DeltaNLef1 transgenic mice, which express NH(2)-terminally truncated Lef1 in the epidermal basal layer. Transgenic mice develop...

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Source

Identifiers

PMID: 17409394
DOI: 10.1158/0008-5472.CAN-06-3427

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17409394-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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