Article
Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jul 1998
Pierce A M, Gimenez-Conti I B, Schneider-Broussard R, Martinez L A, Conti C J, Johnson D G
Abstract excerpt
The p16(INK4a)-cyclin D-retinoblastoma tumor suppressor pathway is disrupted in most human cancers, and it has been suggested that the subsequent release of E2F transcription factors from inhibitory complexes may be a key event in tumor development. We described recently the generation of transge...
Topics
- Animals
- Carrier Proteins
- Cell Cycle Proteins
- DNA-Binding Proteins
- E2F Transcription Factors
- E2F1 Transcription Factor
- Heterozygote
- Keratinocytes
- Mice
- Mice, Knockout
- Mice, Transgenic
- Phenotype
- Retinoblastoma-Binding Protein 1
- Skin Neoplasms
- Transcription Factor DP1