Article
Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jul 1998
Pierce A M, Gimenez-Conti I B, Schneider-Broussard R, Martinez L A, Conti C J, Johnson D G
Abstract excerpt
The p16(INK4a)-cyclin D-retinoblastoma tumor suppressor pathway is disrupted in most human cancers, and it has been suggested that the subsequent release of E2F transcription factors from inhibitory complexes may be a key event in tumor development. We described recently the generation of transgenic mice with E2F1 gene expression targeted to squamous epithelial tissues by a keratin 5 (K5) promoter. In the present...
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