Article
[Apoptosis of peripheral blood lymphocytes in patients with LRRK2-assoctated Parkinson's disease].
Tsitologiia - 1 Jan 2012
Usenko T S, Emel'ianov A K, Iakimovskiĭ A F, Bogan'kova N A, Vavilova T V, Shvartsman A L, Pchelina S N
Abstract excerpt
Mutations in the Leucine Reach Repeat Kinase 2 (LRRK2) gene are the most frequent cause of familial Parkinson's disease (PD). Although the precise physiological and pathological role of LRRK2 is unclear, a direct link between mutant LRRK2 and apoptosis has been suggested. Using flow cytometric analysis (PI+Annexin V(FITC)) we showed increased spontaneous apoptosis of peripheral blood lymphocytes in patients with...
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