Article
Monoallelic and unequal allelic expression of the HTR2A gene in human brain and peripheral lymphocytes.
Biological psychiatry - 15 Dec 2006
Fukuda Yoshiko, Koga Minori, Arai Makoto, Noguchi Emiko, Ohtsuki Tsuyuka, Horiuchi Yasue, Ishiguro Hiroki, Niizato Kazuhiro, Iritani Shyuji, Itokawa Masanari, Arinami Tadao
Abstract excerpt
BACKGROUND: The 102T/C polymorphism of the serotonin 2A receptor (HTR2A) gene is reported to be associated with schizophrenia and other diseases and phenotypes. Altered HTR2A expression has been found in relation to several neuropsychiatric conditions, including depression and schizophrenia. Studies of expression of HTR2A messenger RNA (mRNA) and protein in postmortem brains suggest that the 102C allele might be...
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