Article
Diet-induced weight loss decreases adipose tissue oxygen tension with parallel changes in adipose tissue phenotype and insulin sensitivity in overweight humans.
International journal of obesity (2005) - 1 May 2017
Vink R G, Roumans N J, Čajlaković M, Cleutjens J P M, Boekschoten M V, Fazelzadeh P, Vogel M A A, Blaak E E, Mariman E C, van Baak M A, Goossens G H
Abstract excerpt
BACKGROUND/OBJECTIVES: Although adipose tissue (AT) hypoxia is present in rodent models of obesity, evidence for this in humans is limited. Here, we investigated the effects of diet-induced weight loss (WL) on abdominal subcutaneous AT oxygen tension (pO2), AT blood flow (ATBF), AT capillary density, AT morphology and transcriptome, systemic inflammatory markers and insulin sensitivity in humans....
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