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Article

Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Jan 2007

Anttila S, Huuhka K, Huuhka M, Rontu R, Hurme M, Leinonen E, Lehtimäki T

Abstract excerpt

Several studies have linked 5-HT1A C1019G and BDNF G196A (Val66Met) gene polymorphisms to major depressive disorder (MDD) and the actions of antidepressants. We attempt to show that the interaction between 5-HT1A and BDNF polymorphism predicts the risk of treatment-resistant depression. The sample consists of 119 patients with treatment-resistant MDD and 392 controls. 5-HT1A C1019G and BDNF G196A (Val66Met)...

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Source

Identifiers

PMID: 17401528
DOI: 10.1007/s00702-007-0705-9

Genes

BDNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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