Article
Adefovir dipivoxil treatment of lamivudine-resistant chronic hepatitis B.
Antiviral research - 1 Aug 2007
Dai Chia-Yen, Chuang Wan-Long, Hsieh Ming-Yen, Lee Li-Po, Huang Jee-Fu, Hou Nai-Jen, Lin Zu-Yau, Chen Shinn-Cherng, Hsieh Ming-Yuh, Wang Liang-Yen, Tsai Jun-Fa, Chang Wen-Yu, Yu Ming-Lung
Abstract excerpt
Adefovir dipivoxil (ADV)-resistant mutations have been identified in treating hepatitis B virus (HBV) infection. This study aimed to analyze the response, the incidence of ADV resistance and the virologic characteristics of ADV therapy. A total of 29 CHB patients with confirmed lamivudine (LAM)-resistant HBV were treated with ADV for more than 52 weeks. Serum HBV DNA, HBV genotypes and sequences of HBV polymerase...
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