Article
Novel alternatively spliced ADAM8 isoforms contribute to the aggressive bone metastatic phenotype of lung cancer.
Oncogene - 1 Jul 2010
Hernández I, Moreno J L, Zandueta C, Montuenga L, Lecanda F
Abstract excerpt
ADAMs (a disintegrin and metalloprotease) are transmembrane proteins involved in a variety of physiological processes and tumorigenesis. Recently, ADAM8 has been associated with poor prognosis of lung cancer. However, its contribution to tumorigenesis in the context of lung cancer metastasis remains unknown. Native ADAM8 expression levels were lower in lung cancer cell lines. In contrast, we identified and...
Topics
- ADAM Proteins
- Alternative Splicing
- Base Sequence
- Bone Neoplasms
- Cell Line, Tumor
- Humans
- Lung Neoplasms
- Membrane Proteins
- Molecular Sequence Data
- Neoplasm Invasiveness
- Phenotype