Article
Examining the candidacy of ghrelin as a gene responsible for variation in adult stature in a United Kingdom population with type 2 diabetes.
The Journal of clinical endocrinology and metabolism - 1 Jun 2007
Gueorguiev Maria, Wiltshire Steven, Garcia Edwin A, Mein Charles, Lecoeur Cecile, Kristen Brigitte, Allotey Rebecca, Hattersley Andrew T, Walker Mark, O'rahilly Stephen, Froguel Philippe, Grossman Ashley B, McCarthy Mark I, Hitman Graham A, Korbonits Márta
Abstract excerpt
CONTEXT: Recently, a quantitative trait locus for stature was reported on chromosome 3p26 in patients with type 2 diabetes. OBJECTIVE: Given that ghrelin is a peptide involved in GH release and located on 3p26, we hypothesized that variation within its gene (GHRL) may be responsible for the quantitative trait locus on 3p26. DESIGN: The evidence for linkage around GHRL was refined with the genotyping of an...
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