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Article

Intrarectal transmission, systemic infection, and CD4+ T cell depletion in humanized mice infected with HIV-1.

The Journal of experimental medicine - 16 Apr 2007

Sun Zhifeng, Denton Paul W, Estes Jacob D, Othieno Florence A, Wei Bangdong L, Wege Anja K, Melkus Michael W, Padgett-Thomas Angela, Zupancic Mary, Haase Ashley T, Garcia J Victor

Abstract excerpt

Intrarectal infection between men who have sex with men represents a predominant form of human immunodeficiency virus (HIV) transmission in developed countries. Currently there are no adequate small animal models that recapitulate intrarectal HIV transmission. Here we demonstrate that human lymphocytes generated in situ from hematopoietic stem cells reconstitute the gastrointestinal tract of humanized mice with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17389241
DOI: 10.1084/jem.20062411
PMCID: PMC2118553

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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