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Article

Crystal structure and functional implication of a bacterial cyclic AMP-AMP-GMP synthetase.

Nucleic acids research - 7 May 2021

Ko Tzu-Ping, Wang Yu-Chuan, Tsai Chia-Ling, Yang Chia-Shin, Hou Mei-Hui, Chen Yeh

Abstract excerpt

Mammalian cyclic GMP-AMP synthase (cGAS) and its homologue dinucleotide cyclase in Vibrio cholerae (VcDncV) produce cyclic dinucleotides (CDNs) that participate in the defense against viral infection. Recently, scores of new cGAS/DncV-like nucleotidyltransferases (CD-NTases) were discovered, which produce various CDNs and cyclic trinucleotides (CTNs) as second messengers. Here, we present the crystal structures...

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PMID: 33836064
DOI: 10.1093/nar/gkab165
PMCID: PMC8096243

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