Article
Genetic evidence that apolipoprotein E4 is not a relevant susceptibility factor for cholelithiasis in two high-risk populations.
Journal of lipid research - 1 Jun 2007
Mella Juan G, Schirin-Sokhan Ramin, Rigotti Attilio, Pimentel Fernando, Villarroel Luis, Wasmuth Hermann E, Sauerbruch Tilman, Nervi Flavio, Lammert Frank, Miquel Juan Francisco
Abstract excerpt
Apolipoprotein E (apoE) isoforms are genetic determinants of interindividual variations in lipid metabolism. To assess whether apoE is a genetic risk factor for cholesterol gallstone disease (GD), we analyzed apoE variants in populations from Chile and Germany, two countries with very high prevalence rates of this disease. ApoE genotypes were determined in Chilean gallstone patients (n = 117) and control subjects...
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