Article
Effect of apolipoprotein E polymorphism on bile lipid composition and the formation of cholesterol gallstone.
The American journal of gastroenterology - 1 Jul 2003
Hasegawa Kiyoshi, Terada Sachiyo, Kubota Keiichi, Itakura Hiroshige, Imamura Hiroshi, Ohnishi Shin, Aoki Taku, Ijichi Masayoshi, Saiura Akio, Makuuchi Masatoshi
Abstract excerpt
OBJECTIVE: It remains a matter of controversy whether possession of the apolipoprotein E4 (apoE4) allele is a genetic risk factor for the formation of cholesterol gallstones. The aim of the present study was to test this hypothesis by investigating the effect of apoE4 on bile lipid composition in normal subjects and in patients with cholesterol gallstones and to evaluate the distributions of apoE alleles in these...
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