Article
mRNA expression and BRAF mutation in circulating melanoma cells isolated from peripheral blood with high molecular weight melanoma-associated antigen-specific monoclonal antibody beads.
Clinical chemistry - 1 Apr 2009
Kitago Minoru, Koyanagi Kazuo, Nakamura Takeshi, Goto Yasufumi, Faries Mark, O'Day Steven J, Morton Donald L, Ferrone Soldano, Hoon Dave S B
Abstract excerpt
BACKGROUND: The detection of circulating tumor cells (CTCs) in the peripheral blood of melanoma patients by quantitative real-time reverse-transcription PCR (qRT-PCR) analysis correlates with a poor prognosis. The assessment of CTCs from blood has been difficult because of lack of a good monoclonal antibody (mAb) directed against surface cell antigens to capture melanoma cells. METHODS: Blood was collected...
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