Article
Can loss of apoptosis protect against cancer?
Trends in genetics : TIG - 1 May 2007
Wodarz Dominik, Komarova Natalia
Abstract excerpt
Cells of higher organisms can commit suicide in response to genomic alterations, a process called programmed cell death. Although it is commonly thought that the loss of programmed cell death is required for carcinogenesis, we argue that the situation is more complex and that the loss of programmed cell death can have the converse effect, preventing cancer progression. If the death rate of cancer cells is low,...
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