Article
Apoptosis in cancer.
Carcinogenesis - 1 Mar 2000
Lowe S W, Lin A W
Abstract excerpt
In the last decade, basic cancer research has produced remarkable advances in our understanding of cancer biology and cancer genetics. Among the most important of these advances is the realization that apoptosis and the genes that control it have a profound effect on the malignant phenotype. For example, it is now clear that some oncogenic mutations disrupt apoptosis, leading to tumor initiation, progression or...
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