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Article

How cell death shapes cancer

5 Mar 2015

Abstract excerpt

Apoptosis has been established as a mechanism of anti-cancer defense. Members of the BCL-2 family are critical mediators of apoptotic cell death in health and disease, often found to be deregulated in cancer and believed to lead to the survival of malignant clones. However, over the years, a number of studies pointed out that a model in which cell death resistance unambiguously acts as a barrier against malignant...

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PMID: 25741600
DOI: 10.1038/cddis.2015.20

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