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[Analysis of BRCA1/2 and CHEK2 mutations in ovarian cancer and primary multiple tumors involving the ovaries. Patients of Russian population using biochips].

Molekuliarnaia biologiia - 1 Jan 2000

Fedorova O E, Liubchenko L N, Paiadini Iu G, Kazubskaia T P, Amosenko F A, Gar'kavtseva R F, Zasedatelev A S, Nasedkina T V

Abstract excerpt

Ovarian cancer (OC) is one of the leading cause of cancer death in women. Inherited BRCA1 and BRCA2 mutations strikingly increase OC risk (with lifetime risk estimates ranging at 10-60%). Mutation 1100delC in CHEK2 gene was shown to be associated with breast cancer in women carrying this mutation. Knowledge of the nature and frequency of population-specific mutations in these genes is a critical step in the...

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Source

Identifiers

PMID: 17380889
DOI: 10.1134/s0026893307010062

Genes

BRCA1
CHEK2
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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