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Article

Genetic Analysis of Multiple Primary Malignant Tumors in Women with Breast and Ovarian Cancer.

International journal of molecular sciences - 4 Apr 2023

Savkova Alina, Gulyaeva Lyudmila, Gerasimov Aleksey, Krasil'nikov Sergey

Abstract excerpt

Familial cancer syndromes, which are commonly caused by germline mutations in oncogenes and tumor suppressor genes, are generally considered to be the cause of primary multiple malignant neoplasias (PMMNs). Using targeted genomic sequencing, we screened for eight germline mutations: BRCA1 185delAG, BRCA1 T300G, BRCA1 2080delA, BRCA1 4153delA, BRCA1 5382insC, BRCA2 6174delT, CHEK2 1100delC, and BLM C1642T, which...

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Identifiers

PMID: 37047678
DOI: 10.3390/ijms24076705
PMCID: PMC10095199

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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