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Article

Rare cancer-specific mutations in PIK3CA show gain of function.

Proceedings of the National Academy of Sciences of the United States of America - 27 Mar 2007

Gymnopoulos Marco, Elsliger Marc-André, Vogt Peter K

Abstract excerpt

Fifteen rare cancer-derived mutants of PIK3CA, the gene coding for the catalytic subunit p110alpha of phosphatidylinositol 3-kinase (PI3K), were examined for their biological and biochemical properties. Fourteen of these mutants show a gain of function: they induce rapamycin-sensitive oncogenic transformation of chicken embryo fibroblasts, constitutively activate Akt and TOR-mediated signaling, and show enhanced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17376864
DOI: 10.1073/pnas.0701005104
PMCID: PMC1838453

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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