Article
Cluster headache and the hypocretin receptor 2 reconsidered: a genetic association study and meta-analysis.
Cephalalgia : an international journal of headache - 1 Aug 2015
Weller Claudia M, Wilbrink Leopoldine A, Houwing-Duistermaat Jeanine J, Koelewijn Stephany C, Vijfhuizen Lisanne S, Haan Joost, Ferrari Michel D, Terwindt Gisela M, van den Maagdenberg Arn M J M, de Vries Boukje
Abstract excerpt
BACKGROUND: Cluster headache is a severe neurological disorder with a complex genetic background. A missense single nucleotide polymorphism (rs2653349; p.Ile308Val) in the HCRTR2 gene that encodes the hypocretin receptor 2 is the only genetic factor that is reported to be associated with cluster headache in different studies. However, as there are conflicting results between studies, we re-evaluated its role in...
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